Vitamin D status: a U-shaped relationship for SARS-CoV-2 seropositivity in UK healthcare workers.

Sebastian T LuggWilliam R MackayAduragbemi A FaniyiSian E FaustiniCraig WebsterJoanne E DuffyMartin HewisonAdrian M ShieldsDhruv ParekhAlex G RichterAaron ScottDavid R Thickett

Published in: BMJ open respiratory research (2022)

Our study has shown a U-shaped relationship for COVID-19 seropositivity in UK healthcare workers. Further investigation is required to determine whether high VD levels can have a detrimental effect on susceptibility to COVID-19 infection. Future randomised clinical trials of VD supplementation could potentially identify 'optimal' VD levels, allowing for targeted therapeutic treatment for those at risk.

Keyphrases

sars cov
clinical trial
respiratory syndrome coronavirus
coronavirus disease
open label
cross sectional
study protocol
double blind
cancer therapy
phase ii
current status
randomized controlled trial
drug delivery
smoking cessation