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Senescent cells exacerbate chronic inflammation and contribute to periodontal disease progression in old mice.

Ruben Aquino-MartinezBrittany A EckhardtJennifer L RowseyDaniel G FraserSundeep KhoslaJoshua N FarrDavid G Monroe
Published in: Journal of periodontology (2021)
Accumulation of senescent osteocytes contributes to deterioration of the periodontal environment by exacerbating chronic inflammation and reducing regeneration in old age. Cellular senescence is a cell-intrinsic response to DNA damage, and a host-related mechanism associated with aging that could potentiate inflammation induced by bacterial components.
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