Senescent cells exacerbate chronic inflammation and contribute to periodontal disease progression in old mice.

Ruben Aquino-MartinezBrittany A EckhardtJennifer L RowseyDaniel G FraserSundeep Khosla Joshua N Farr David G Monroe

Published in: Journal of periodontology (2021)

Accumulation of senescent osteocytes contributes to deterioration of the periodontal environment by exacerbating chronic inflammation and reducing regeneration in old age. Cellular senescence is a cell-intrinsic response to DNA damage, and a host-related mechanism associated with aging that could potentiate inflammation induced by bacterial components.

Keyphrases

oxidative stress
dna damage
induced apoptosis
stem cells
single cell
dna repair
endothelial cells
type diabetes
cell therapy
mesenchymal stem cells
drug induced
adipose tissue
high fat diet induced
cell death
wild type