Inhibition of NAD+-dependent metabolic processes induces cellular necrosis and tumor regression in rhabdomyosarcoma models.
Grace B McKay-CorkumVictor J CollinsChoh YeungTakeshi ItoSameer H IssaqDavid O HollandKsenia VulikhYiping ZhangUnsun LeeHaiyan LeiArnulfo MendozaJack F ShernMarielle E YoheKazutoshi YamamotoKelli M WilsonJiuping JiBaktiar O KarimCraig J ThomasMurali C KrishnaLeonard M NeckersChristine M HeskePublished in: Clinical cancer research : an official journal of the American Association for Cancer Research (2023)
RMS is highly vulnerable to NAMPT inhibition. These findings underscore the need for further clinical study of this class of agents for this malignancy.
Keyphrases