Effect of CPAP on cardiovascular events in minimally symptomatic OSA: long-term follow-up of the MOSAIC randomised controlled trial.
Ivan TangChris D TurnbullDushendree SenSonya CraigMalcolm KohlerJohn R StradlingPublished in: BMJ open respiratory research (2021)
The effect of continuous positive airway pressure (CPAP) on cardiovascular events is uncertain in minimally symptomatic obstructive sleep apnoea. Previous 2-year follow-up data from the Multicentre Obstructive Sleep Apnoea Intervention Cardiovascular (MOSAIC) trial showed a marginal reduction in cardiovascular events with CPAP therapy. We now present long-term MOSAIC study follow-up data. Median (first quartile, third quartile) follow-up was 5.0 (2.2, 5.0) and 3.7 (1.5, 5.0) years for CPAP and standard care, respectively. Compared to standard care, CPAP had no statistically significant effect on the risk of cardiovascular events (HR=0.83, p=0.54, 95% CI 0.46-1.51).
Keyphrases
- cardiovascular events
- positive airway pressure
- obstructive sleep apnea
- sleep apnea
- coronary artery disease
- study protocol
- cardiovascular disease
- healthcare
- palliative care
- randomized controlled trial
- clinical trial
- electronic health record
- physical activity
- quality improvement
- sleep quality
- big data
- pain management
- affordable care act
- data analysis
- cross sectional
- artificial intelligence
- stem cells
- open label
- phase ii
- bone marrow
- phase iii
- deep learning