miR-122-mediated translational repression of PEG10 and its suppression in human hepatocellular carcinoma.

Yu-Chiau ShyuTung-Liang LeeMu-Jie LuJim-Ray ChenRong-Nan ChienHuang-Yang ChenJi-Fan LinAnn-Ping TsouYu-Hsien ChenChia-Wen HsiehTing-Shuo Huang

Published in: Journal of translational medicine (2016)

miR-122 suppresses PEG10 expression via direct binding to the 3'-UTR of the PEG10 transcript. Therefore, while PEG10 could not be an ideal diagnostic biomarker for HCC but its upregulation in HCC tissue still has predictive value for HCC prognosis.

Keyphrases

cell proliferation
drug delivery
long non coding rna
poor prognosis
long noncoding rna
endothelial cells
signaling pathway
induced pluripotent stem cells
binding protein
pluripotent stem cells