Explicit interaction information from WikiPathways in RDF facilitates drug discovery in the Open PHACTS Discovery Platform.

Ryan A Miller Peter M Woollard Egon L WilighagenDaniela DiglesMartina KutmonAntonis LoizouAndra WaagmeesterStefan SengerChris T A Evelo

Published in: F1000Research (2018)

Open PHACTS is a pre-competitive project to answer scientific questions developed recently by the pharmaceutical industry. Having high quality biological interaction information in the Open PHACTS Discovery Platform is needed to answer multiple pathway related questions. To address this, updated WikiPathways data has been added to the platform. This data includes information about biological interactions, such as stimulation and inhibition. The platform's Application Programming Interface (API) was extended with appropriate calls to reference these interactions. These new methods of the Open PHACTS API are available now.

Keyphrases

high throughput
minimally invasive
drug discovery
small molecule
electronic health record
health information
big data
machine learning
drug induced
data analysis