Pannexin 1 Modulates Angiogenic Activities of Human Endothelial Colony-Forming Cells Through IGF-1 Mechanism and Is a Marker of Senescence.
Ting-Yi TienYih-Jer WuCheng-Huang SuChin-Ling HsiehBo-Jeng WangYi-Nan LeeYeu SuHung-I YehPublished in: Arteriosclerosis, thrombosis, and vascular biology (2023)
Panx1 expression is upregulated in human ECFCs/EPCs with replication-induced senescence and during aging. Angiogenic potential of senescent ECFCs is improved by Panx1 reduction through increased IGF-1 production via activation of the FAK-ERK axis following calcium influx reduction. Our findings provide new strategies to evaluate EPC activities and rejuvenate senescent EPCs for therapeutic angiogenesis.
Keyphrases
- endothelial cells
- high glucose
- pi k akt
- induced apoptosis
- vascular endothelial growth factor
- signaling pathway
- poor prognosis
- dna damage
- cell cycle arrest
- cell proliferation
- pluripotent stem cells
- oxidative stress
- cell death
- endoplasmic reticulum stress
- risk assessment
- long non coding rna
- growth hormone
- human health