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An RB-1 loss of function gene signature as a tool to predict response to neoadjuvant chemotherapy plus anti-HER2 agents: a substudy of the NeoALTTO trial (BIG 1-06).

Emanuela RisiChiara BiagioniMatteo BenelliIlenia MigliaccioAmelia McCartneyMartina BonechiCristina GuarducciFlorentine HilbersSerena Di CosimoJens HuoberDario RomagnoliGiulia BoccaliniStefania VitaleChristos SotiriouLaura BiganzoliAngelo Di LeoLuca Malorni
Published in: Therapeutic advances in medical oncology (2019)
These results indicate RBsig may add valuable information to HER2 and HR expression, which may in turn inform treatment choices. HR+/HER2+/RBsig Low breast cancers exhibited the poorest pathological response following chemotherapy plus H. Accordingly, in such patients, endocrine therapy in combination with H and, possibly, a CDK4/6 inhibitor, may potentially prove to be a more effective treatment.
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