Phase II Investigation of TVB-2640 (denifanstat) with Bevacizumab in Patients with First Relapse High-Grade Astrocytoma.
William James KellyAdolfo Enrique Diaz DuqueJoel E MichalekBrandon KonkelLaura CaflischYidong ChenSarath Chand PathuriVinu Madhusudanannair KunnuparampilJohn FloydAndrew J BrennerPublished in: Clinical cancer research : an official journal of the American Association for Cancer Research (2023)
In this phase II study of relapsed high-grade astrocytoma, TVB-2640 was found to be a well-tolerated oral drug that could be safely combined with bevacizumab. The favorable safety profile and response signals support the initiation of a larger multicenter trial of TVB-2640 plus bevacizumab in astrocytoma.
Keyphrases
- high grade
- phase ii
- open label
- phase ii study
- clinical trial
- metastatic colorectal cancer
- low grade
- phase iii
- placebo controlled
- double blind
- study protocol
- acute myeloid leukemia
- acute lymphoblastic leukemia
- locally advanced
- cross sectional
- multiple myeloma
- diffuse large b cell lymphoma
- rectal cancer
- squamous cell carcinoma
- randomized controlled trial
- hodgkin lymphoma
- adverse drug
- drug induced