Neocurromycin A, a new GRP78 downregulator from Streptomyces sp. RAI364.
Yoichi HayakawaRyodai YaguchiMinami AkimotoShoko KimataTeppei KawaharaPublished in: The Journal of antibiotics (2020)
A new curromycin-related compound, neocurromycin A (2), was isolated from the fermented broth of Streptomyces sp. RAI364. The molecular formula of 2 was established as C35H44N4O7 by ESI-MS and the structure was elucidated by NMR spectroscopic analyses. Neocurromycin A showed selective cytotoxicity against MKN45 human gastric cancer cells in a nutrient-deprived medium with an IC50 of 380 nM and inhibited the expression of the molecular chaperone GRP78 in HT1080 G-L cells in the presence of 10 mM of 2-deoxyglucose with an IC50 of 1.7 µM.
Keyphrases
- induced apoptosis
- endoplasmic reticulum stress
- ms ms
- endothelial cells
- poor prognosis
- mass spectrometry
- magnetic resonance
- multiple sclerosis
- cell cycle arrest
- positron emission tomography
- molecular docking
- single molecule
- cell surface
- long non coding rna
- binding protein
- endoplasmic reticulum
- molecular dynamics simulations
- drug induced
- pet ct