Regulatory Variants Modulate Protein Kinase C α (PRKCA) Gene Expression in Human Heart.
Liang LiLizhi ZhangPhilip F BinkleyWolfgang SadeeDanxin WangPublished in: Pharmaceutical research (2017)
The haplotype carrying rs9909004 influences PRKCA expression in the heart and is associated with traits linked to heart failure, potentially affecting therapy of heart failure.
Keyphrases
- heart failure
- gene expression
- protein kinase
- endothelial cells
- poor prognosis
- atrial fibrillation
- left ventricular
- acute heart failure
- cardiac resynchronization therapy
- dna methylation
- genome wide
- transcription factor
- induced pluripotent stem cells
- copy number
- pluripotent stem cells
- binding protein
- stem cells
- mesenchymal stem cells
- bone marrow
- smoking cessation