Single-Molecule Spatial Transcriptomics of Human Thoracic Aortic Aneurysms Uncovers Calcification-Related CARTPT -Expressing Smooth Muscle Cells.

Y Eugene Chen Yang ZhaoHao FengJane MacaulayYing TangZain Sultan Guizhen Zhao Yanhong Guo Jifeng Zhang Bo Yang Yuqing Eugene Chen

Published in: Arteriosclerosis, thrombosis, and vascular biology (2023)

-expressing SMC subtype enriched in male human TAA samples. Our functional studies suggest that human CART promotes osteochondrogenic switch of aortic SMCs, potentially leading to medial calcification of the thoracic aorta.

Keyphrases

endothelial cells
single molecule
aortic valve
induced pluripotent stem cells
pulmonary artery
pluripotent stem cells
spinal cord
chronic kidney disease
left ventricular
single cell
coronary artery
atomic force microscopy
fluorescent probe