Undernutrition upregulated PD-1 and PD-L1 expression and downregulated immune signaling pathways in mice with visceral leishmaniasis. The signaling pathways and hub genes may serve as drug targets or intervention targets for the treatment of leishmaniasis patients with undernutrition.
Keyphrases
- signaling pathway
- pi k akt
- induced apoptosis
- high fat diet induced
- epithelial mesenchymal transition
- randomized controlled trial
- cell proliferation
- genome wide
- early onset
- gene expression
- wild type
- insulin resistance
- poor prognosis
- metabolic syndrome
- dna methylation
- adipose tissue
- long non coding rna
- adverse drug
- transcription factor
- electronic health record