Expression of PD-L1 Is Increased by Methionine Restriction Using Recombinant Methioninase in Human Colorectal Cancer Cells.

Kohei MizutaByung Mo KangQinghong HanYutaro KubotaSei MorinagaMotokazu SatoMichael BouvetYasunori TomeKotaro NishidaRobert M Hoffman

Published in: Cancer genomics & proteomics (2024)

Methionine restriction with rMETase up-regulates PD-L1 expression in human colorectal cancer cells and the combination of rMETase and ICIs may have the potential to improve immunotherapy in human colorectal cancer.

Keyphrases

endothelial cells
induced pluripotent stem cells
pluripotent stem cells
poor prognosis
long non coding rna
human health
amino acid