Postoperative abdominal sepsis induces selective and persistent changes in CTCF binding within the MHC-II region of human monocytes.

Benedikt Hermann SieglerMarc AltvaterJan Niklas Thon Christopher NeuhausChristoph ArensFlorian UhleChristoph LichtensternMarkus Alexander WeigandSebastian Weiterer

Published in: PloS one (2021)

Our experiments demonstrate differential and persisting alterations of CTCF occupancy within the MHC-II, accompanied by selective changes in the expression of spatially related HLA class II genes, indicating an important role of CTCF in modulating the transcriptional response of immunocompromised human monocytes during critical illness.

Keyphrases

endothelial cells
induced pluripotent stem cells
dendritic cells
poor prognosis
gene expression
pluripotent stem cells
intensive care unit
peripheral blood
transcription factor
binding protein
septic shock
long non coding rna
dna binding
acute respiratory distress syndrome
extracorporeal membrane oxygenation