Novel B cell subsets as potential biomarkers in Idiopathic Inflammatory Myopathies: insights into disease pathogenesis and disease activity.
Raúl F Reyes-HuertaVladimir Mandujano-LópezGuadalupe Velásquez-OrtizBeatriz Alcalá-CarmonaMaría J Ostos-PradoYatzil Reyna-JuárezDavid E Meza-SánchezGuillermo Juárez-VegaNancy R Mejía-DomínguezJiram Torres-RuizDiana Gómez-MartinJosé Luis Maravillas-MonteroPublished in: Journal of leukocyte biology (2024)
Idiopathic inflammatory myopathies are a heterogeneous group of rare autoimmune disorders characterized by progressive muscle weakness and the histopathologic findings of inflammatory infiltrates in muscle tissue. Although their pathogenesis remains indefinite, the association of autoantibodies with clinical manifestations and the evidence of high effectiveness of depleting therapies suggest that B cells could be implicated. Therefore, we explored the landscape of peripheral B cells in this disease by multiparametric flow cytometry, finding significant numerical decreases in memory and double negative subsets, as well as an expansion of the naïve compartment relative to healthy controls, that contribute to defining disease-associated B cell subset signatures and correlating with different clinical features of patients. Additionally, we determined the potential value of these subsets as diagnostic biomarkers, thus positioning B cells as neglected key elements possibly participating in idiopathic inflammatory myopathies onset or development.
Keyphrases
- disease activity
- systemic lupus erythematosus
- oxidative stress
- flow cytometry
- rheumatoid arthritis
- multiple sclerosis
- end stage renal disease
- peripheral blood
- skeletal muscle
- randomized controlled trial
- ejection fraction
- chronic kidney disease
- rheumatoid arthritis patients
- prognostic factors
- dna methylation
- drug induced