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Randomized Controlled Trial of Urokinase versus Placebo for Nondraining Malignant Pleural Effusion.

Eleanor K MishraAmelia O CliveGenevieve H WillsHelen E DaviesAndrew E StantonMohamed Al-AloulAlan Hart-ThomasJustin PepperellMatthew EvisonTarek SabaRichard Neil HarrisonAnur GuhanMatthew E CallisterRamamurthy SathyamurthySunita RehalJohn P CorcoranRobert HallifaxIoannis PsallidasNicky RussellRachel ShawMelissa DobsonJohn M WrightsonAlex WestYun Chor Gary LeeAndrew J NunnRobert F MillerNick A MaskellNajib M Rahman
Published in: American journal of respiratory and critical care medicine (2019)
Use of intrapleural urokinase does not reduce dyspnea or improve pleurodesis success compared with placebo and cannot be recommended as an adjunct to pleurodesis. Other palliative treatments should be used. Improvements in hospital stay, radiographic appearance, and survival associated with urokinase require further evaluation. Clinical trial registered with ISRCTN (12852177) and EudraCT (2008-000586-26).
Keyphrases
  • randomized controlled trial
  • clinical trial
  • double blind
  • phase iii
  • study protocol
  • healthcare
  • advanced cancer
  • palliative care
  • open label
  • systematic review
  • emergency department
  • acute care
  • free survival