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Visible-Light-Mediated Generation of Acyl Radicals from Triazine Esters.

Tao WangYuan-Yuan ZongWan-Zhong FengLi-Zhu WuQiang Liu
Published in: The Journal of organic chemistry (2023)
Acyl radicals are significant synthetic active species in organic synthesis. However, their generation via green and compatible methods remains challenging. Herein, we report an unprecedented visible-light-mediated approach for generating aryl acyl radicals from readily available triazine esters. This protocol with mild and redox-neutral conditions affords a diverse array of oxindoles attached to alcohol groups in a single operation. The recycling of leaving groups and a range of visible-light-mediated reactions using triazine ester as an acyl radical precursor demonstrate the synthetic potential of this methodology.
Keyphrases
  • visible light
  • fatty acid
  • randomized controlled trial
  • solid phase extraction
  • high throughput
  • mass spectrometry
  • alcohol consumption
  • high density