Impact of sirtuin-1 expression on H3K56 acetylation and oxidative stress: a double-blind randomized controlled trial with resveratrol supplementation.
Simona BoGabriele TogliattoRoberto GambinoValentina PonzoGiusy LombardoRosalba RosatoMaurizio CassaderMaria Felice BrizziPublished in: Acta diabetologica (2018)
We provide new knowledge on H3K56ac and SIRT-1 association in T2DM. These data suggest that boosting SIRT-1 expression/activation may impact redox homeostasis in these patients. ClinicalTrials.gov Identifier NCT02244879.
Keyphrases
- oxidative stress
- randomized controlled trial
- poor prognosis
- end stage renal disease
- ischemia reperfusion injury
- ejection fraction
- newly diagnosed
- healthcare
- peritoneal dialysis
- binding protein
- clinical trial
- electronic health record
- long non coding rna
- induced apoptosis
- metabolic syndrome
- diabetic rats
- big data
- weight loss
- signaling pathway
- glycemic control
- electron transfer