Human Hepatic Transporter Signature Peptides for Quantitative Targeted Absolute Proteomics: Selection, Digestion Efficiency, and Peptide Stability.

Ayano MoriTakeshi MasudaShingo ItoSumio Ohtsuki

Published in: Pharmaceutical research (2022)

The signature peptides selected in the present study enabled the reliable quantification of human hepatic transporters. The QTAP protocol using these optimal signature peptides provides quantitative data on hepatic transporters usable for integrated pharmacokinetic studies.

Keyphrases

endothelial cells
induced pluripotent stem cells
high resolution
randomized controlled trial
pluripotent stem cells
mass spectrometry
electronic health record
drug delivery
cancer therapy
artificial intelligence
deep learning
case control
data analysis