A Coclinical Radiogenomic Validation Study: Conserved Magnetic Resonance Radiomic Appearance of Periostin-Expressing Glioblastoma in Patients and Xenograft Models.

Pascal O ZinnSanjay K SinghAikaterini KotrotsouIslam HassanGinu ThomasMarkus Martin LuediAhmed ElakkadNabil ElshafeeyTagwa IdrisJennifer MosleyJoy GuminGregory N FullerJohn F de GrootVeera BaladandayuthapaniErik P SulmanAshok J KumarRaymond SawayaFrederick F LangDavid Piwnica-WormsRivka R Colen

Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2018)

We determined causality between radiomic texture features and POSTN expression levels in a preclinical model with clinical validation. Our biologically validated radiomic pipeline also showed the potential application for human-mouse matched coclinical trials.

Keyphrases

magnetic resonance
end stage renal disease
endothelial cells
chronic kidney disease
poor prognosis
newly diagnosed
ejection fraction
peritoneal dialysis
prognostic factors
transcription factor
magnetic resonance imaging
computed tomography
long non coding rna
cell therapy
human health
pluripotent stem cells