1H, 13C, and 15N backbone assignments of the C-terminal region of the human retinoic acid-induced protein 2.
Andras LangNishit GoradiaHarriet WikmanStefan WernerMatthias WilmannsOliver OhlenschlãgerPublished in: Biomolecular NMR assignments (2020)
Retinoic acid-induced protein 2 is a human protein of 530 residues encoded by the RAI2 gene (Q9Y5P3; RAI2_HUMAN). RAI2 is a novel tumor suppressor protein whose depletion in breast cancer cell lines results in the downregulation of several genes associated with differentiation along with increased invasiveness and aggressive tumor phenotype of the cells. The role of the protein is specified to be a transcriptional regulator that promotes chromosomal stability and hence controls the expression of several regulators of cancer and metastasis. Structurally, RAI2 remains an unknown entity and, hence, to obtain a detailed view on the structure function relationship we report the 1H, 13C, and 15N resonance assignments for the backbone and side chain nuclei of the C-terminal region (a.a. 303-451 of UniProt Q9Y5P3) of RAI2.
Keyphrases
- endothelial cells
- protein protein
- binding protein
- high glucose
- transcription factor
- amino acid
- induced pluripotent stem cells
- gene expression
- squamous cell carcinoma
- poor prognosis
- cell proliferation
- signaling pathway
- induced apoptosis
- pluripotent stem cells
- dna methylation
- genome wide
- papillary thyroid
- diabetic rats
- drug induced
- endoplasmic reticulum stress
- pi k akt
- cell cycle arrest
- squamous cell