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Genetic Association and Expression Analyses of the Phosphatidylinositol-4-Phosphate 5-Kinase (PIP5K1C) Gene in Alcohol Use Disorder-Relevance for Pain Signaling and Alcohol Use.

Ji Soo LeeJill L SorcherAllison D RosenRuslan DamadzicHui SunMelanie SchwandtMarkus HeiligJohn KellyKelsey L MauroAudrey LuoDaniel RosoffChristine MuenchJeesun JungZachary A KaminskyFalk W Lohoff
Published in: Alcoholism, clinical and experimental research (2018)
Our discovery sample shows that genetic variants in PIP5K1C are associated with AUD in the AA group, and acute alcohol exposure leads to up-regulation of PIP5K1C, potentially explaining a mechanism underlying the increased risk for chronic pain conditions in individuals with AUD.
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