Genetic Association and Expression Analyses of the Phosphatidylinositol-4-Phosphate 5-Kinase (PIP5K1C) Gene in Alcohol Use Disorder-Relevance for Pain Signaling and Alcohol Use.
Ji Soo LeeJill L SorcherAllison D RosenRuslan DamadzicHui SunMelanie SchwandtMarkus HeiligJohn KellyKelsey L MauroAudrey LuoDaniel RosoffChristine MuenchJeesun JungZachary A KaminskyFalk W LohoffPublished in: Alcoholism, clinical and experimental research (2018)
Our discovery sample shows that genetic variants in PIP5K1C are associated with AUD in the AA group, and acute alcohol exposure leads to up-regulation of PIP5K1C, potentially explaining a mechanism underlying the increased risk for chronic pain conditions in individuals with AUD.
Keyphrases
- alcohol use disorder
- chronic pain
- genome wide
- pain management
- copy number
- poor prognosis
- protein kinase
- liver failure
- small molecule
- respiratory failure
- high throughput
- aortic dissection
- tyrosine kinase
- dna methylation
- binding protein
- alcohol consumption
- spinal cord injury
- spinal cord
- intensive care unit
- neuropathic pain
- transcription factor
- extracorporeal membrane oxygenation
- acute respiratory distress syndrome