The ketogenic diet does not improve cardiac function and blunts glucose oxidation in ischemic heart failure.

Kim L HoQutuba KarwiFaqi WangCory WaggLiyan ZhangSai PanidarapuBrandon ChenSimran PherwaniAmanda A GreenwellGavin Y Oudit John R Ussher Gary D Lopaschuk

Published in: Cardiovascular research (2024)

We conclude that the ketogenic diet does not improve heart function in failing hearts, due to ketogenic diet-induced excessive fatty acid oxidation in the ischemic heart and a decrease in insulin-stimulated glucose oxidation.

Keyphrases

heart failure
hydrogen peroxide
fatty acid
physical activity
weight loss
atrial fibrillation
type diabetes
blood glucose
ischemia reperfusion injury
electron transfer
visible light
cerebral ischemia
glycemic control
weight gain
nitric oxide
skeletal muscle
metabolic syndrome
insulin resistance
blood brain barrier