Multiomics characterization of mouse hepatoblastoma identifies yes-associated protein 1 target genes.

Tomas C RodriguezSuet-Yan KwanJordan L SmithSina DadafarinChern-Horng WuErik J SontheimerWen Xue

Published in: Hepatology (Baltimore, Md.) (2022)

Our chromatin-profiling techniques define the regulatory frameworks underlying HB and identify YAP1-regulated gene/enhancer pairs. JDP2 is an extensively validated target with YAP1-dependent expression in human HB cell lines and hepatic malignancies.

Keyphrases

genome wide
transcription factor
genome wide identification
dna methylation
endothelial cells
binding protein
poor prognosis
copy number
multidrug resistant
gene expression
induced pluripotent stem cells
dna damage
genome wide analysis
pluripotent stem cells
oxidative stress
bioinformatics analysis