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B cell targeting in CAR T cell therapy: Side effect or driver of CAR T cell function?

Gregory M ChenJan Joseph MelenhorstKai Tan
Published in: Science translational medicine (2022)
Chimeric antigen receptor (CAR) T cell therapies targeting CD19 and CD22 have been successful for treating B cell cancers, but CAR T cells targeting non-B cell cancers remain unsuccessful. We propose that rather than being strictly a side effect of therapy, the large number of CAR interactions with normal B cells may be a key contributor to clinical CAR T cell responses.
Keyphrases
  • cell therapy
  • cancer therapy
  • stem cells
  • induced apoptosis
  • mesenchymal stem cells
  • drug delivery
  • oxidative stress
  • signaling pathway
  • nk cells
  • replacement therapy