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Kai Tan

Scopus Author ID ORCID

Publication Activity (10 Years)

Years Active: 2019-2023
Publications (10 Years): 21

Top Venues

Genes & development

Blood

Science advances

Proceedings of the National Academy of Sciences of the United States of America

University of Pennsylvania

Washington University in Saint Louis (PHD)

This page only lists publications with an associated author ORCID identifier.

Affiliation History

University of Pennsylvania Jul 1o 2020

United States

Professor :: Pediatrics

Education History

Washington University in Saint Louis Aug 1o 1998 - May 1o 2004

United States

PHD :: Genetics

Publications

Kai Tan, Jason Xu, Changya Chen, Tiffaney Vincent, Petri Polonen, Jianzhong Hu, Satoshi Yoshimura, Wenbao Yu, Jonathan Sussman, Chia-Hui Chen, Elizabeth Li, Caroline Diorio, Rawan Shraim, Haley Newman, Lahari Uppuluri, Alexander Li, Gregory Chen, Shovik Bandyopadhyay, David Wu, Yang-Yang Ding, Jessica Xu, Tristan Lim, Miles Hsu, Anusha Thadi, Kyung Jin Ahn, Chi-Yun Wu, Jacqueline Peng, Yusha Sun, Alice Wang, Rushabh Mehta, David Frank, Lauren Meyer, Mignon Loh, Elizabeth Raetz, Zhiguo Chen, Brent Wood, Meenakshi Devidas, Kimberly Dunsmore, Stuart Winter, Ti-Cheng Chang, Gang Wu, Stanley B Pounds, Nancy R Zhang, William Carroll, Stephen Hunger, Kathrin Bernt, Jun J Yang, Charles G Mullighan, David Teachey
Identification and targeting of treatment resistant progenitor populations in T-cell Acute Lymphoblastic Leukemia. Research square (2023)
Alexandra U Zezulin, Daniel Yen, Darwin Ye, Elizabeth D Howell, Erica Bresciani, Jamie Diemer, Jian-Gang Ren, Mohd Hafiz Ahmad, Lucio H Castilla, Ivo P Touw, Andy J Minn, Wei Tong, P Paul Liu, Kai Tan, Wenbao Yu, Nancy A Speck
RUNX1 is required in granulocyte-monocyte progenitors to attenuate inflammatory cytokine production by neutrophils. Genes & development (2023)
Alexandra U Zezulin, Darwin Ye, Elizabeth Howell, Daniel Yen, Erica Bresciani, Jamie Diemer, Jian-Gang Ren, Mohd Hafiz Ahmad, Lucio H Castilla, Ivo P Touw, Andy J Minn, Wei Tong, P Paul Liu, Kai Tan, Wenbao Yu, Nancy A Speck
RUNX1 is required in granulocyte-monocyte progenitors to attenuate inflammatory cytokine production by neutrophils. bioRxiv : the preprint server for biology (2023)
Yiqing Yang, Melanie D Mumau, Joanna Tober, Qin Zhu, Laura F Bennett, Courtney Hong, Derek C Sung, Thomas Keller, Yasin Uzun, Peng Gao, Swapnil Shewale, Mei Chen, Jisheng Yang, Xiaowen Chen, Steven A Thomas, Kai Tan, Nancy A Speck, Mark L Kahn
Endothelial MEKK3-KLF2/4 signaling integrates inflammatory and hemodynamic signals during definitive hematopoiesis. Blood 139 (19) (2022)
Gregory M Chen, Jan Joseph Melenhorst, Kai Tan
B cell targeting in CAR T cell therapy: Side effect or driver of CAR T cell function? Science translational medicine 14 (650) (2022)
Gregory M Chen, Chia-Hui Chen, Jessica Perazzelli, Stephan A Grupp, David M Barrett, Kai Tan
Characterization of leukemic resistance to CD19-targeted CAR T-cell therapy through deep genomic sequencing. Cancer immunology research (2022)
Adam J Wolpaw, Liron D Grossmann, Jessica L Dessau, May M Dong, Bailey J Aaron, Patricia A Brafford, Darya Volgina, Guillem Pascual-Pasto, Alba Rodriguez-Garcia, Yasin Uzun, Marie Arsenian Henriksson, Daniel J Powell, Kristopher R Bosse, Andrew Kossenkov, Kai Tan, Michael D Hogarty, John M Maris, Chi Van Dang
Epigenetic state determines inflammatory sensing in neuroblastoma. Proceedings of the National Academy of Sciences of the United States of America 119 (6) (2022)
Gregory M Chen, Changya Chen, Rajat K Das, Peng Gao, Chia-Hui Chen, Shovik Bandyopadhyay, Yang-Yang Ding, Yasin Uzun, Wenbao Yu, Qin Zhu, Regina M Myers, Stephan A Grupp, David M Barrett, Kai Tan
Integrative Bulk and Single-Cell Profiling of Premanufacture T-cell Populations Reveals Factors Mediating Long-Term Persistence of CAR T-cell Therapy. Cancer discovery 11 (9) (2021)
Yuxuan Hu, Tao Peng, Lin Gao, Kai Tan
CytoTalk: De novo construction of signal transduction networks using single-cell transcriptomic data. Science advances 7 (16) (2021)
Brian Estevez, Sara Borst, Danuta Jarocha, Varun Sudunagunta, Michael V Gonzalez, James P Garifallou, Hakon H Hakonarson, Peng Gao, Kai Tan, Paul Liu, Sumedha Bagga, Nicholas Holdreith, Wei Tong, Nancy A Speck, Deborah L French, Paul Gadue, Mortimer Poncz
RUNX-1 haploinsufficiency causes a marked deficiency of megakaryocyte-biased hematopoietic progenitor cells. Blood 137 (19) (2021)
Changya Chen, Wenbao Yu, Fatemeh Alikarami, Qi Qiu, Chia-Hui Chen, Jennifer Flournoy, Peng Gao, Yasin Uzun, Li Fang, James W Davenport, Yuxuan Hu, Qin Zhu, Kai Wang, Clara Libbrecht, Alex S Felmeister, Isaiah Rozich, Yang-Yang Ding, Stephen P Hunger, Carolyn A Felix, Hao Wu, Patrick A Brown, Erin M Guest, David M Barrett, Kathrin Maria Bernt, Kai Tan
Single-cell multiomics reveals increased plasticity, resistant populations and stem-cell-like blasts in KMT2A-rearranged leukemia. Blood (2021)
Yang-Yang Ding, Hannah Kim, Kellyn Madden, Joseph P Loftus, Gregory M Chen, David Hottman Allen, Ruitao Zhang, Jason Xu, Chia-Hui Chen, Yuxuan Hu, Sarah K Tasian, Kai Tan
Network Analysis Reveals Synergistic Genetic Dependencies for Rational Combination Therapy in Philadelphia Chromosome-Like Acute Lymphoblastic Leukemia. Clinical cancer research : an official journal of the American Association for Cancer Research 27 (18) (2021)
Elizabeth D Howell, Amanda D Yzaguirre, Peng Gao, Raphael Lis, Bing He, Melike Lakadamyali, Shahin Rafii, Kai Tan, Nancy A Speck
Efficient hemogenic endothelial cell specification by RUNX1 is dependent on baseline chromatin accessibility of RUNX1-regulated TGFβ target genes. Genes & development 35 (21-22) (2021)
Yasin Uzun, Hao Wu, Kai Tan
Predictive modeling of single-cell DNA methylome data enhances integration with transcriptome data. Genome research 31 (1) (2020)
Jingmei Hsu, Hsuan-Ting Huang, Chung-Tsai Lee, Avik Choudhuri, Nicola K Wilson, Brian J Abraham, Victoria Moignard, Iwo Kucinski, Shuqian Yu, R Katherine Hyde, Joanna Tober, Xiongwei Cai, Yan Li, Yalin Guo, Song Yang, Michael Superdock, Eirini Trompouki, Fernando J Calero-Nieto, Alireza Ghamari, Jing Jiang, Peng Gao, Long Gao, Vy Nguyen, Anne L Robertson, Ellen M Durand, Katie L Kathrein, Iannis Aifantis, Scott A Gerber, Wei Tong, Kai Tan, Alan B Cantor, Yi Zhou, P Paul Liu, Richard A Young, Berthold Göttgens, Nancy A Speck, Leonard I Zon
CHD7 and Runx1 interaction provides a braking mechanism for hematopoietic differentiation. Proceedings of the National Academy of Sciences of the United States of America 117 (38) (2020)
Peng Gao, Changya Chen, Elizabeth D Howell, Yan Li, Joanna Tober, Yasin Uzun, Bing He, Long Gao, Qin Zhu, Arndt F Siekmann, Nancy A Speck, Kai Tan
Transcriptional regulatory network controlling the ontogeny of hematopoietic stem cells. Genes & development 34 (13-14) (2020)
Bing He, Peng Gao, Yang-Yang Ding, Chia-Hui Chen, Gregory Chen, Changya Chen, Hannah Kim, Sarah K Tasian, Stephen P Hunger, Kai Tan
Diverse noncoding mutations contribute to deregulation of cis-regulatory landscape in pediatric cancers. Science advances 6 (30) (2020)
Gregory M Chen, Andrew Azzam, Yang-Yang Ding, David M Barrett, Stephan A Grupp, Kai Tan
Dissecting the Tumor-Immune Landscape in Chimeric Antigen Receptor T-cell Therapy: Key Challenges and Opportunities for a Systems Immunology Approach. Clinical cancer research : an official journal of the American Association for Cancer Research 26 (14) (2020)
Tao Peng, Qin Zhu, Penghang Yin, Kai Tan
SCRABBLE: single-cell RNA-seq imputation constrained by bulk RNA-seq data. Genome biology 20 (1) (2019)
Jonathan S Packer, Qin Zhu, Chau Huynh, Priya Sivaramakrishnan, Elicia Preston, Hannah Dueck, Derek J Stefanik, Kai Tan, Cole Trapnell, Junhyong Kim, Robert H Waterston, John Isaac Murray
A lineage-resolved molecular atlas of C. elegans embryogenesis at single-cell resolution. Science (New York, N.Y.) 365 (6459) (2019)
Suzanne P MacFarland, Koumudi Naraparaju, Radhika Iyer, Peng Guan, Venkatadri Kolla, Yuxuan Hu, Kai Tan, Garrett M Brodeur
Mechanisms of Entrectinib Resistance in a Neuroblastoma Xenograft Model. Molecular cancer therapeutics 19 (3) (2019)

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Publication Activity (10 Years)

Top Topics

Top Venues

Kai Tan