The role of USP7-YY1 interaction in promoting colorectal cancer growth and metastasis.
Zhi-Ying ShaoWen-Dong YangHui QiuZhi-Hong HeMeng-Ru LuQi ShenJin DingJun-Nian ZhengJin BaiPublished in: Cell death & disease (2024)
Colorectal cancer (CRC) remains a significant global health issue with high incidence and mortality. Yin Yang 1 (YY1) is a powerful transcription factor that acts dual roles in gene activation and repression. High expression level of YY1 has been reported in CRC, indicating the existence of stable factors of YY1 in CRC cells. We aimed to identify the key molecules and underlying mechanisms responsible for stabilizing YY1 expression in CRC. Mass spectrometry analysis was utilized to identify USP7 as a potential molecule that interacted with YY1. Mechanically, USP7 stabilizes YY1 expression at the protein level by interfering its K63 linkage ubiquitination. YY1 exerts its oncogenic function through transcriptionally activating TRIAP1 but suppressing LC3B. In addition, at the pathological level, there is a positive correlation between the expression of YY1 and the budding of CRC. This study has revealed the intricate interplay between YY1 and USP7 in CRC, suggesting that they could serve as novel therapeutic targets or predictive biomarkers for CRC patients.
Keyphrases
- poor prognosis
- transcription factor
- mass spectrometry
- global health
- binding protein
- end stage renal disease
- signaling pathway
- public health
- chronic kidney disease
- long non coding rna
- type diabetes
- induced apoptosis
- ejection fraction
- gene expression
- ms ms
- small molecule
- prognostic factors
- cell proliferation
- patient reported outcomes
- dna binding
- risk assessment
- coronary artery disease
- human health
- amino acid
- patient reported
- capillary electrophoresis