Tocilizumab combination therapy or monotherapy or methotrexate monotherapy in methotrexate-naive patients with early rheumatoid arthritis: 2-year clinical and radiographic results from the randomised, placebo-controlled FUNCTION trial.
Gerd R BurmesterWilliam F RigbyRonald F van VollenhovenJonathan KayAndrea Rubbert-RothRicardo BlancoAlysha KadvaSophie DimonacoPublished in: Annals of the rheumatic diseases (2017)
NCT01007435; Results.
Keyphrases
- combination therapy
- placebo controlled
- rheumatoid arthritis
- phase iii
- study protocol
- double blind
- phase ii
- clinical trial
- open label
- high dose
- disease activity
- randomized controlled trial
- phase ii study
- interstitial lung disease
- hiv infected
- rheumatoid arthritis patients
- juvenile idiopathic arthritis
- low dose
- squamous cell carcinoma
- systemic lupus erythematosus