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Harmonised culture procedures minimise but do not eliminate mesenchymal stromal cell donor and tissue variability in a decentralised multicentre manufacturing approach.

Sandra Calcat-I-CerveraErika RendraEleonora ScacciaFrancesco AmadeoVivien HansonBettina WilmPatricia MurrayTimothy O'BrienArthur TaylorKaren Bieback
Published in: Stem cell research & therapy (2023)
These results show the heterogeneous behaviour and regenerative properties of MSCs as a reflection of intrinsic tissue-origin properties while providing evidence that the use of harmonised culture procedures can reduce but do not eliminate inter-lab and operator differences.
Keyphrases
  • mesenchymal stem cells
  • stem cells
  • cell therapy
  • bone marrow
  • single cell
  • clinical trial
  • study protocol
  • umbilical cord
  • cross sectional
  • randomized controlled trial