E-Cadherin expression in human tumors: a tissue microarray study on 10,851 tumors.

Eike BurandtFelix LübbersmeyerNatalia GorbokonFranziska BüscheckAndreas M LuebkeAnne MenzMartina KluthClaudia Hube-MaggAndrea HinschDoris HöflmayerSören WeidemannChristoph FrauneKatharina MöllerFrank JacobsenPatrick LebokTill Sebastian ClauditzGuido SauterRonald SimonRia UhligWaldemar WilczakStefan SteurerSarah MinnerRainer KrechDavid DumTill KrechAndreas Holger MarxChristian Bernreuther

Published in: Biomarker research (2021)

E-Cadherin is consistently expressed in various epithelial cancers. Down-regulation or loss of E-Cadherin expression in cancers arising from E-Cadherin positive tissues as well as E-Cadherin neo-expression in cancers arising from E-Cadherin negative tissues is linked to cancer progression and may reflect tumor dedifferentiation.

Keyphrases

poor prognosis
endothelial cells
binding protein
long non coding rna
papillary thyroid
squamous cell carcinoma
childhood cancer
induced pluripotent stem cells
lymph node metastasis
pluripotent stem cells