Can we Save the rectum by watchful waiting or TransAnal surgery following (chemo)Radiotherapy versus Total mesorectal excision for early REctal Cancer (STAR-TREC)? Protocol for the international, multicentre, rolling phase II/III partially randomized patient preference trial evaluating long-course concurrent chemoradiotherapy versus short-course radiotherapy organ preservation approaches.
Simon P Bachnull nullPublished in: Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland (2022)
STAR-TREC will prospectively evaluate contrasting therapeutic strategies and implement new measures including a smaller mesorectal target volume, two-step response assessment and non-operative management for complete response. The trial will yield important information to guide routine management of patients with early-stage rectal cancer.
Keyphrases
- rectal cancer
- locally advanced
- phase ii
- clinical trial
- open label
- phase iii
- double blind
- neoadjuvant chemotherapy
- early stage
- placebo controlled
- study protocol
- minimally invasive
- randomized controlled trial
- sentinel lymph node
- case report
- coronary artery bypass
- cross sectional
- acute coronary syndrome
- photodynamic therapy
- cancer therapy
- social media