Plasmodium 18S rRNA of intravenously administered sporozoites does not persist in peripheral blood.

Sean C MurphyAndrew S IshizukaZachary P BillmanTayla M OlsenAnnette M SeilieMing ChangNahum SmithVorada ChuenchobSumana ChakravartyB Kim Lee SimStefan H I KappeStephen L HoffmanRobert A Seder

Published in: Malaria journal (2018)

Beyond the first few hours after injection, sporozoite-derived Plasmodium 18S rRNA was not detected in peripheral blood. Diagnostics based on 18S rRNA are unlikely to be confounded by sporozoite inocula in human clinical trials.

Keyphrases

peripheral blood
clinical trial
endothelial cells
plasmodium falciparum
induced pluripotent stem cells
pluripotent stem cells
randomized controlled trial
phase ii
open label
phase iii