Human Colon Cancer-Derived Clostridioides difficile Strains Drive Colonic Tumorigenesis in Mice.
Julia L DrewesJie ChenNicholas O MarkhamReece J KnippelJada C DomingueAda J TamJune L ChanLana KimMadison McMannCourtney StevensChristine M DejeaSarah TomkovichJohn MichelJames Robert WhiteFuad MohammadVictoria L CampodónicoCody N HeiserXinqun WuShaoguang WuHua DingPatricia J SimnerKaren C CarrollMartha J ShrubsoleRobert A AndersSeth T WalkChristian JobinFengyi WanD Borden LacyFranck HousseauKen S LauCynthia L SearsPublished in: Cancer discovery (2022)
Colorectal cancer is a leading cause of cancer and cancer-related deaths worldwide, with a multifactorial etiology that likely includes procarcinogenic bacteria. Using human colon cancer specimens, culturing, and murine models, we demonstrate that chronic infection with the enteric pathogen C. difficile is a previously unrecognized contributor to colonic tumorigenesis. See related commentary by Jain and Dudeja, p. 1838. This article is highlighted in the In This Issue feature, p. 1825.