Targeted delivery of LXR-agonists to atherosclerotic lesions mediated by polydiacetylene micelles.
Lucie JamgotchianLaurent DevelRobert ThaiLucie PoupelThierry HubyEmmanuel GautierWilfried Le GoffPhilippe LesnikEdmond GravelEric DorisPublished in: Nanoscale (2023)
We report the development of compact and stabilized micelles incorporating a synthetic LXR agonist prodrug for the passive targeting of atherosclerotic lesions and therapeutic intervention. In vivo studies showed that the nanohybrid micelles exhibited favorable pharmacokinetics/biodistribution and were able to upregulate, to some extent, LXR target genes with no alteration of lipid metabolism.