Impact of hematopoietic cell transplantation on myocardial fibrosis in young patients with sickle cell disease.

Akshay Sharma Subodh R Selukar Yu Bi Anthony Merlocco Cara E MorinChris GoodeParul RaiJeffrey A TowbinJane Silva Hankins Stephen Gottschalk Brandon M Triplett Jason Nathaniel Johnson

Published in: Blood (2024)

Serial cardiovascular magnetic resonance evaluation of children and young adults with SCD who underwent hematopoietic cell transplantation showed mean ECV, representing diffuse myocardial fibrosis, decreased 3.4% from baseline to 12 months posttransplantation. This trial was registered at www.clinicaltrials.gov as #NCT04362293.

Keyphrases

sickle cell disease
young adults
magnetic resonance
left ventricular
study protocol
clinical trial
childhood cancer
phase iii
phase ii
liver fibrosis
randomized controlled trial
heart failure
contrast enhanced
computed tomography