Triple-negative breast cancer (TNBC) is a highly heterogeneous breast cancer subtype, which is also characterized by the aggressive phenotype, high recurrence rate, and poor prognosis. Antibody-drug conjugate (ADC) is a monoclonal antibody with a cytotoxic payload connected by a linker. ADC is gaining more and more attention as a targeted anti-cancer agent. Clinical studies of emerging ADC drugs such as sacituzumab govitecan and trastuzumab deruxtecan in patients with metastatic breast cancer (including TNBC) are progressing rapidly. In view of its excellent clinical efficacy and good tolerability, Sacituzumab govitecan gained accelerated approval by the FDA for the treatment of advanced metastatic TNBC in 2020. This review discusses the treatment status and challenges in TNBC, with an emphasis on the current status of ADC development and clinical trials in TNBC and metastatic breast cancer. We also summarize the clinical experience and future exploration directions of ADC development for TNBC patients.
Keyphrases
- metastatic breast cancer
- poor prognosis
- diffusion weighted imaging
- diffusion weighted
- current status
- monoclonal antibody
- clinical trial
- long non coding rna
- end stage renal disease
- cancer therapy
- small cell lung cancer
- squamous cell carcinoma
- newly diagnosed
- chronic kidney disease
- ejection fraction
- contrast enhanced
- randomized controlled trial
- working memory
- open label
- young adults
- double blind
- phase ii
- patient reported outcomes
- free survival
- breast cancer risk