Potential therapeutic targets discovery by transcriptome analysis of an in vitro human gastric signet ring carcinoma model.
Kyoko YamaguchiTomoyasu YoshihiroHiroshi AriyamaMamoru ItoMichitaka NakanoYuichiro SembaJumpei NogamiKenji TsuchihashiTakuji YamauchiShohei UenoTaichi IsobeKoji ShindoTaiki MoriyamaKenoki OhuchidaMasafumi NakamuraYoshihiro NagaoTetsuo IkedaMakoto HashizumeHiroyuki KonomiTakehiro TorisuTakanari KitazonoTomohiro KanayamaHiroyuki TomitaYoshinao OdaHitoshi KusabaTakahiro MaedaKoichi AkashiEishi BabaPublished in: Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association (2022)
E-cadherin deficient SRCCs might gain cell motility through upregulation of MMPs. CXCL12-positive cancer-associated fibroblasts could serve to maintain cancer-cell survival as a niche. MMPs and the CXCL12/CXCR4 axis represent promising candidates as novel therapeutic targets for E-cadherin-deficient SRCC.
Keyphrases
- endothelial cells
- papillary thyroid
- single cell
- small molecule
- squamous cell
- cell therapy
- induced pluripotent stem cells
- poor prognosis
- cell proliferation
- pluripotent stem cells
- biofilm formation
- high throughput
- extracellular matrix
- wild type
- lymph node metastasis
- escherichia coli
- pseudomonas aeruginosa
- childhood cancer
- long non coding rna
- bone marrow