Artemisia iwayomogi (AI) is a perennial herb found in Korea. Its ground parts are dried and used in food and traditional medicine for treating hepatitis, inflammation, cholelithiasis, and jaundice. In this study, the anti-obesity effects of single compounds isolated from AI extracts on adipose tissue were investigated. Results demonstrated that caffeoylquinic acid analogs strongly inhibited adipocyte differentiation from 3T3-L1 preadipocytes and reduced neutral lipids in differentiated adipocytes. Accordingly, lipid accumulation in adipocytes decreased, and lipid droplets became granulated. Caffeoylquinic acid analogs suppressed the expression of adipocyte differentiation marker genes, namely, Cebpa, Lep, and Fabp4, but it induced the expression of Ucp1, Ppargc1a, and Fgf21, which are browning biomarkers. Therefore, caffeoylquinic acid analogs from AI inhibited preadipocyte differentiation and induced adipose tissue browning, suggesting that these compounds could be promising therapeutic agents for obesity.
Keyphrases
- adipose tissue
- insulin resistance
- high fat diet induced
- molecular docking
- high fat diet
- poor prognosis
- metabolic syndrome
- artificial intelligence
- high glucose
- type diabetes
- binding protein
- fatty acid
- weight loss
- oxidative stress
- weight gain
- drug induced
- mass spectrometry
- high resolution
- machine learning
- diabetic rats
- climate change
- endothelial cells
- gene expression
- high speed