Positive Allosteric Modulation of α5-GABAA Receptors Reverses Stress-Induced Alterations in Dopamine System Function and Prepulse Inhibition of Startle.
Alexandra M McCoyThomas D PrevotMd Yenus MianJames M CookAlan FrazerEtienne L SibilleFlavia R CarrenoDaniel J LodgePublished in: The international journal of neuropsychopharmacology (2022)
Our results demonstrate that pharmacological intervention augmenting α5-GABAAR function, but not α5 overexpression in itself, can reverse stress-induced deficits related to PTSD in a rodent model, providing a potential site of therapeutic intervention to treat comorbid psychosis in PTSD.