Lactococcus lactis carrying the pValac eukaryotic expression vector coding for IL-4 reduces chemically-induced intestinal inflammation by increasing the levels of IL-10-producing regulatory cells.
Bianca Mendes SouzaTatiane Melo PreisserVanessa Bastos PereiraMeritxell Zurita-TurkCamila Prósperi de CastroVanessa Pecini da CunhaRafael Pires de OliveiraAna Cristina Gomes-SantosAna Maria Caetano de FariaDenise Carmona Cara MachadoJean-Marc ChatelVasco Ariston de Carvalho AzevedoPhilippe LangellaAnderson MiyoshiPublished in: Microbial cell factories (2016)
This study shows that L. lactis MG1363 FnBPA(+) (pValac::dts::IL-4) is a good candidate to maintain the anti-inflammatory and proinflammatory balance in the gastrointestinal tract, increasing the levels of IL-10-secreting regulatory cells and, thus, demonstrating the effectiveness of this novel DNA delivery-based strategy.