Efficacy and safety of dihydroartemisinin-piperaquine versus artemether-lumefantrine for treatment of uncomplicated Plasmodium falciparum malaria in Ugandan children: a systematic review and meta-analysis of randomized control trials.

Dawit Getachew AssefaEden Dagnachew ZelekeDelayehu BekeleHanna Amanuel TesfahuneiEmnet GetachewMichele JosephTsegahun Manyazewal

Published in: Malaria journal (2021)

Compared to AL, DHA-PQ appeared to reduce treatment failure and gametocyte carriage in Ugandan children. This may trigger DHA-PQ to become the first-line treatment option. Both treatments were safe and well-tolerated.

Keyphrases

plasmodium falciparum
young adults
clinical trial
fatty acid
randomized controlled trial
open label
double blind
phase ii
replacement therapy
drug administration