Hypofractionated radiotherapy combined with bevacizumab plus low-dose ifosfamide, carboplatin, and etoposide as second-line chemoradiotherapy for progressing spinal diffuse midline glioma, H3K27-altered: illustrative case.

Shintaro NakayasuMasahiro TanjiMegumi UtoYasuhide TakeuchiYasuhide MakinoEtsuko Yamamoto HattoriYukinori TeradaNoritaka SanoYohei MineharuTakashi MizowakiYoshiki Arakawa

Published in: Journal of neurosurgery. Case lessons (2024)

Spinal DMG is a malignant tumor with a poor prognosis. However, treatment with additional HFRT combined with BEV plus low-dose ICE may inhibit tumor progression to prolong the progression-free period and survival. https://thejns.org/doi/10.3171/CASE2464.

Keyphrases

poor prognosis
low dose
long non coding rna
spinal cord
radiation therapy
locally advanced
high dose
early stage
rectal cancer
spinal cord injury
squamous cell carcinoma
randomized controlled trial
low grade
radiation induced
clinical trial
small cell lung cancer
phase iii