Effects of adiposity on the human plasma proteome: observational and Mendelian randomisation estimates.
Lucy J GoudswaardJoshua A BellDavid A HughesLaura J CorbinKlaudia WalterGeorge Davey SmithNicole SoranzoJohn DaneshEmanuele Di AngelantonioWillem Hendrik OuwehandNicholas A WatkinsDavid J RobertsAdam S ButterworthIngeborg HersNicholas John TimpsonPublished in: International journal of obesity (2005) (2021)
This study provides evidence for a broad impact of adiposity on the human proteome. Proteins strongly altered by BMI include those involved in regulating appetite, sex hormones and inflammation; such proteins are also enriched for cardiovascular disease-related genes. Altogether, results help focus attention onto new proteomic signatures of obesity-related disease.
Keyphrases
- insulin resistance
- weight gain
- cardiovascular disease
- weight loss
- endothelial cells
- type diabetes
- metabolic syndrome
- body mass index
- oxidative stress
- working memory
- adipose tissue
- high fat diet induced
- skeletal muscle
- induced pluripotent stem cells
- cross sectional
- gene expression
- dna methylation
- coronary artery disease
- pluripotent stem cells