Decreased expression of TIGIT on CD14 + monocytes correlates with clinical features and laboratory parameters of patients with primary Sjögren's syndrome.
Ping ZhaoCheng PengXin ChangWei ChengYanhong YangYu ShenChao SunXiuyuan FengCuiping LiuJian WuPublished in: Clinical rheumatology (2023)
Our study suggested that decreased TIGIT expression on CD14 + monocytes was associated with the clinical manifestations, disease activity, and prognosis of pSS patients. TIGIT + CD14 + monocytes may present as a potential target and a biomarker of the prognosis for immunomodulatory therapy in pSS. Key Points • The expression of TIGIT+CD14+ monocytes significantly decreased in pSS patients compared to HC. • There was a negative correlation between TIGIT+CD14+ monocytes and the disease activity of pSS. • TIGIT+CD14+ monocyte expression was associated with the clinical manifestations, autoantibodies, IgG, and prognosis of pSS patients.
Keyphrases
- disease activity
- systemic lupus erythematosus
- rheumatoid arthritis
- poor prognosis
- end stage renal disease
- ejection fraction
- newly diagnosed
- dendritic cells
- peripheral blood
- rheumatoid arthritis patients
- ankylosing spondylitis
- stem cells
- immune response
- juvenile idiopathic arthritis
- binding protein
- patient reported outcomes
- bone marrow
- long non coding rna