Plaque-associated human microglia accumulate lipid droplets in a chimeric model of Alzheimer's disease.

Christel ClaesEmma Pascal DanhashJonathan HasselmannJean Paul ChadarevianSepideh Kiani ShabestariWhitney E EnglandTau En LimJorge Luis Silva HidalgoRobert C SpitaleHayk DavtyanMathew Blurton Jones

Published in: Molecular neurodegeneration (2021)

Altogether, these results indicate lipid droplet accumulation occurs in human DAM xMGs in AD, but is reduced in TREM2-R47H DAM xMGs, as it occurs secondary to TREM2-mediated changes in plaque proximity and reactivity.

Keyphrases

endothelial cells
induced pluripotent stem cells
coronary artery disease
pluripotent stem cells
cognitive decline
single cell
inflammatory response
fatty acid
spinal cord injury
cell therapy
mesenchymal stem cells
neuropathic pain
stem cells
spinal cord