Using an in-vivo syngeneic spontaneous metastasis model identifies ID2 as a promoter of breast cancer colonisation in the brain.
Magdalena KijewskaCarmen ViskiFrances TurrellAmanda FitzpatrickAntoinette van WeverwijkQiong GaoMarjan IravaniClare M IsackePublished in: Breast cancer research : BCR (2019)
This study identifies ID2 as a key regulator of breast cancer metastasis to the brain. Our data support a model in which breast cancer cells that have disseminated to the brain upregulate ID2 expression in response to astrocyte-secreted BMP7 and this serves to support metastatic expansion. Moreover, elevated ID2 expression identifies breast cancer patients at increased risk of developing metastatic relapse in the brain.
Keyphrases
- resting state
- white matter
- poor prognosis
- genome wide
- squamous cell carcinoma
- small cell lung cancer
- functional connectivity
- breast cancer cells
- transcription factor
- dna methylation
- cerebral ischemia
- gene expression
- mesenchymal stem cells
- electronic health record
- bone marrow
- big data
- artificial intelligence
- bone regeneration
- free survival
- breast cancer risk