Towards a unified open access dataset of molecular interactions.
Pablo PorrasElisabet BarreraAlan BridgeNoemi Del-ToroGianni CesareniMargaret DuesburyHenning HermjakobMarta IannuccelliIgor JurisicaMax KotlyarLuana LicataRuth C LoveringDavid John LynnBirgit H M MeldalBindu NanduriKalpana PaneerselvamSimona PanniChiara PastrelloMatteo PellegriniLivia PerfettoNegin RahimzadehPrashansa RatanSylvie Ricard-BlumLukasz SalwinskiGautam ShirodkarAnjalia ShrivastavaSandra E OrchardPublished in: Nature communications (2020)
The International Molecular Exchange (IMEx) Consortium provides scientists with a single body of experimentally verified protein interactions curated in rich contextual detail to an internationally agreed standard. In this update to the work of the IMEx Consortium, we discuss how this initiative has been working in practice, how it has ensured database sustainability, and how it is meeting emerging annotation challenges through the introduction of new interactor types and data formats. Additionally, we provide examples of how IMEx data are being used by biomedical researchers and integrated in other bioinformatic tools and resources.