Autophagy in major human diseases.
Daniel J KlionskyGiulia PetroniRavi K AmaravadiEric H BaehreckeAndrea BalabioPatricia BoyaJosé Manuel Bravo-San PedroKen CadwellFrancesco CecconiAugustine M K ChoiMary E ChoiCharleen T ChuPatrice CodognoMaria Isabel ColomboAna Maria CuervoVojo DereticIvan ĐikićZvulun ElazarEeva-Liisa EskelinenGian Maria FimiaDavid A GewirtzDouglas R GreenMalene HansenMarja JäätteläTerje JohansenGábor JuhászVassiliki KarantzaClaudine KraftGuido KroemerNicholas T KtistakisSharad KumarCarlos López-OtínKay F MacleodFrank MadeoJennifer MartinezAlicia MeléndezNoboru MizushimaChristian MünzJosef M PenningerRushika M PereraMauro PiacentiniFulvio M ReggioriDavid C RubinszteinKevin M RyanJunichi SadoshimaLaura SantambrogioLuca ScorranoHans-Uwe SimonAnna Katharina SimonAnne SimonsenAlexandra StolzNektarios TavernarakisSharon A ToozeTamotsu YoshimoriJunying YuanZhenyu YueQing ZhongLorenzo GalluzziFederico PietrocolaPublished in: The EMBO journal (2021)
Autophagy is a core molecular pathway for the preservation of cellular and organismal homeostasis. Pharmacological and genetic interventions impairing autophagy responses promote or aggravate disease in a plethora of experimental models. Consistently, mutations in autophagy-related processes cause severe human pathologies. Here, we review and discuss preclinical data linking autophagy dysfunction to the pathogenesis of major human disorders including cancer as well as cardiovascular, neurodegenerative, metabolic, pulmonary, renal, infectious, musculoskeletal, and ocular disorders.