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Local connectivity and synaptic dynamics in mouse and human neocortex.

Luke CampagnolaStephanie C SeemanThomas ChartrandLisa KimAlex HoggarthClare R GamlinShinya ItoJessica TrinhPasha A DavoudianCristina RadaelliMean-Hwan KimTravis A HageThomas BraunLauren AlfilerJulia AndradePhillip BohnRachel DalleyAlex HenrySara KebedeMukora AliceDavid SandmanGrace WilliamsRachael LarsenCorinne TeeterTanya L DaigleKyla BerryNadezhda I DotsonRachel EnstromMelissa GorhamMadison T HuppSamuel Dingman LeeKiet NgoPhilip R NicovichLydia PotekhinaShea RansfordAmanda GaryJeff GoldyDelissa A McMillenTrangthanh H PhamMichael TieuLa' Akea SivertsMiranda WalkerColin FarrellMartin SchroedterClifford R SlaughterbeckCharles CobbsRichard EllenbogenRyder P GwinnC Dirk KeeneAndrew L KoJeffrey G OjemannDaniel L SilbergeldDaniel CareyTamara CasperKirsten CrichtonMichael ClarkNick DeeLauren EllingwoodJessica GloeMatthew KrollJosef SulcHerman TungKatherine WadhwaniKrissy BrounerTom EgdorfMichelle MaxwellMedea McGrawChristina Alice PomAugustin RuizJasmine BombenDavid FengNika HejaziniaShu ShiAaron SzaferWenjing YinJohn PhillipsAmy BernardLuke EspositoFlorence D D'OraziSusan M SunkinKimberly A SmithBosiljka TasicAnton ArkhipovStaci SorensenEd S LeinChristof KochGabe MurphyHongkui ZengTim Jarsky
Published in: Science (New York, N.Y.) (2022)
We present a unique, extensive, and open synaptic physiology analysis platform and dataset. Through its application, we reveal principles that relate cell type to synaptic properties and intralaminar circuit organization in the mouse and human cortex. The dynamics of excitatory synapses align with the postsynaptic cell subclass, whereas inhibitory synapse dynamics partly align with presynaptic cell subclass but with considerable overlap. Synaptic properties are heterogeneous in most subclass-to-subclass connections. The two main axes of heterogeneity are strength and variability. Cell subclasses divide along the variability axis, whereas the strength axis accounts for substantial heterogeneity within the subclass. In the human cortex, excitatory-to-excitatory synaptic dynamics are distinct from those in the mouse cortex and vary with depth across layers 2 and 3.
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